Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T80165
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| Former ID |
TTDR00988
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| Target Name |
Short transient receptor potential channel 6
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| Gene Name |
TRPC6
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| Synonyms |
STrpC6; TRP6; TRPC6
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| Target Type |
Research
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| Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
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| BioChemical Class |
Transient receptor potential catioin channel
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| UniProt ID | |||||
| Sequence |
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE EKSQNTEDLAELIRELGEKLSMEPNQEETNR |
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| Blocker (channel blocker) | 2-APB | Drug Info | [1] | ||
| ACAA | Drug Info | [1] | |||
| KB-R7943 | Drug Info | [1] | |||
| ML9 | Drug Info | [1] | |||
| Activator | 20-HETE | Drug Info | [1] | ||
| flufenamate | Drug Info | [1] | |||
| hyp 9 | Drug Info | [2] | |||
| lysophosphatidylcholine | Drug Info | [1] | |||
| OAG | Drug Info | [3] | |||
| SAG | Drug Info | [3] | |||
| SLG | Drug Info | [3] | |||
| Pathways | |||||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| Nephrin/Neph1 signaling in the kidney podocyte | |||||
| EPO signaling pathway | |||||
| PAR1-mediated thrombin signaling events | |||||
| Reactome | Effects of PIP2 hydrolysis | ||||
| TRP channels | |||||
| Role of second messengers in netrin-1 signaling | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Platelet homeostasis | |||||
| Netrin-1 signaling | |||||
| GPCR downstream signaling | |||||
| Effects of PIP2 hydrolysis | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). | ||||
| REF 2 | Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77. | ||||
| REF 3 | Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. | ||||
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