Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T6DU
|
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| Former ID |
DIB020589
|
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| Drug Name |
OAG
|
||||
| Synonyms |
1-oleoyl-2-acetyl-sn-glycerol
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H42O5
|
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| InChI |
InChI=1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10+
|
||||
| InChIKey |
PWTCCMJTPHCGMS-ZHACJKMWSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Short transient receptor potential channel 3 | Target Info | Activator | [2] | |
| Short transient receptor potential channel 6 | Target Info | Activator | [2] | ||
| TRPC2 | Target Info | Activator | [3] | ||
| TRPC7 | Target Info | Activator | [4] | ||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gammaendothelinpathway:Endothelins | ||||
| Nephrin/Neph1 signaling in the kidney podocyte | |||||
| EPO signaling pathway | |||||
| PAR1-mediated thrombin signaling events | |||||
| Reactome | Effects of PIP2 hydrolysis | ||||
| TRP channels | |||||
| Role of second messengers in netrin-1 signalingR-HSA-114508:Effects of PIP2 hydrolysis | |||||
| Role of second messengers in netrin-1 signaling | |||||
| WikiPathways | Platelet homeostasis | ||||
| Netrin-1 signaling | |||||
| GPCR downstream signaling | |||||
| Effects of PIP2 hydrolysisWP2572:Primary Focal Segmental Glomerulosclerosis FSGS | |||||
| Effects of PIP2 hydrolysis | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2436). | ||||
| REF 2 | Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. | ||||
| REF 3 | A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. | ||||
| REF 4 | Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70. | ||||
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