Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N7MS
|
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| Former ID |
DIB018743
|
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| Drug Name |
ACAA
|
||||
| Synonyms |
ACA
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C21H23NO3
|
||||
| InChI |
InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
|
||||
| InChIKey |
GAMRBCZMOOMBSQ-CCEZHUSRSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | TRPM8 protein | Target Info | Blocker (channel blocker) | [2] | |
| Short transient receptor potential channel 6 | Target Info | Blocker (channel blocker) | [3] | ||
| Long transient receptor potential channel 2 | Target Info | Blocker (channel blocker) | [4] | ||
| Short transient receptor potential channel 3 | Target Info | Blocker (channel blocker) | [5] | ||
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | ||||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| Nephrin/Neph1 signaling in the kidney podocyte | |||||
| EPO signaling pathway | |||||
| PAR1-mediated thrombin signaling eventspi3kplctrkpathway:Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channelsR-HSA-114508:Effects of PIP2 hydrolysis | ||||
| TRP channels | |||||
| Role of second messengers in netrin-1 signalingR-HSA-3295583:TRP channelsR-HSA-114508:Effects of PIP2 hydrolysis | |||||
| Role of second messengers in netrin-1 signaling | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Platelet homeostasis | |||||
| Netrin-1 signaling | |||||
| GPCR downstream signaling | |||||
| Effects of PIP2 hydrolysisWP1885:Platelet homeostasis | |||||
| Effects of PIP2 hydrolysis | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2443). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500). | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). | ||||
| REF 4 | Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488). | ||||
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