Drug Information

Drug General Information
Drug ID
D0G2BS
Former ID
DNC004850
Drug Name
2-(4-Methyl-piperazin-1-yl)-quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527370]
Structure
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2D MOL

3D MOL
Formula
C14H17N3
Canonical SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3C=C2
InChI
1S/C14H17N3/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15-14/h2-7H,8-11H2,1H3
InChIKey
HOMWNUXPSJQSSU-UHFFFAOYSA-N
PubChem Compound ID
5013
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Inhibitor [525484]
5-hydroxy-tryptamine 3B receptor Target Info Inhibitor [525484]
Histamine H3 receptor Target Info Inhibitor [527370]
KEGG Pathway Serotonergic synapsehsa04726:Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transportR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transportWP2670:Iron uptake and transportWP727:Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527370J Med Chem. 2005 Jan 13;48(1):306-11.2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.
Ref 525484J Med Chem. 1999 May 6;42(9):1556-75.Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
Ref 527370J Med Chem. 2005 Jan 13;48(1):306-11.2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.

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