Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I8ZZ
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| Former ID |
DNC007625
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| Drug Name |
Relcovaptan
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Discontinued in Phase 2 | [1], [2] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C28H27Cl2N3O7S
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| InChI |
InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1
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| InChIKey |
CEBYCSRFKCEUSW-NAYZPBBASA-N
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| CAS Number |
CAS 150375-75-0
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7980662, 8187129, 14863085, 14887572, 26753276, 43118261, 50038302, 50105680, 53378720, 53786778, 57314191, 85789081, 103294911, 104008209, 104322008, 117568927, 127611794, 134340560, 134344830, 135017277, 135651080, 137249508, 140278682, 162023296, 162248707, 178100473, 180370993, 184538721, 198968262, 230321120, 241375877, 242486676, 249617536, 252156434, 252159999, 252361308, 252451002
|
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| Target and Pathway | |||||
| Target(s) | Vasopressin V1a receptor | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2200). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004942) | ||||
| REF 3 | J Med Chem. 2007 Oct 4;50(20):4976-85. Epub 2007 Sep 12.Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. | ||||
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