Drug Information

Drug General Information
Drug ID
D0M9RE
Former ID
DIB009950
Drug Name
ARI-809
Synonyms
ARI-809; Aldose reductase inhibitors (diabetes); CP-744809; Aldose reductase inhibitors (diabetes), Pfizer
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Preclinical [549081]
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C13H9ClN2O4S
Canonical SMILES
S(=O)(=O)(c1c(c2c(o1)ccc(c2)Cl)C)c1n[nH]c(=O)cc1
CAS Number
CAS 111477-47-5
PubChem Compound ID
6420118
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [528451]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 549081Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032059)
Ref 528451A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes. 2006 Oct;55(10):2757-62.

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