Drug General Information
Drug ID
D0O8FW
Former ID
DNC009675
Drug Name
EPIANDROSTERONE
Drug Type
Small molecular drug
Indication Discovery agent Phase 3 [524778]
Structure
Download
2D MOL

3D MOL

Formula
C19H30O2
Canonical SMILES
CC12CCC(CC1CCC3C2CCC4(C3CCC4=O)C)O
InChI
1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3
InChIKey
QGXBDMJGAMFCBF-UHFFFAOYSA-N
CAS Number
CAS 481-29-8
PubChem Compound ID
Target and Pathway
Target(s) Glucose-6-phosphate dehydrogenase Target Info Inhibitor [529971]
BioCyc Pathway Pentose phosphate pathway
Pentose phosphate pathway (oxidative branch)
KEGG Pathway Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Central carbon metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Pentose Phosphate Pathway
Warburg Effect
Reactome TP53 Regulates Metabolic Genes
WikiPathways Sulfation Biotransformation Reaction
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Cori Cycle
Metabolism of carbohydrates
Pentose Phosphate Pathway
Glutathione metabolism
References
Ref 524778ClinicalTrials.gov (NCT02151006) Does Dehydro Epiandrosterone (DHEA) Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response?. U.S. National Institutes of Health.
Ref 529971Bioorg Med Chem. 2009 Mar 15;17(6):2483-9. Epub 2009 Feb 4.Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.

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