Target Information

Target General Infomation
Target ID
T63484
Former ID
TTDR00008
Target Name
Glucose-6-phosphate dehydrogenase
Gene Name
G6PD
Synonyms
G6PD
Target Type
Clinical Trial
Disease Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10: J40-J44, J47]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
Catalyzesthe rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
BioChemical Class
Short-chain dehydrogenases reductases
Target Validation
T63484
UniProt ID
P11413
EC Number
EC 1.1.1.49
Sequence
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
Drugs and Mode of Action
Drug(s) Prasterone Drug Info Approved Chronic obstructive pulmonary disease [527619]
EPIANDROSTERONE Drug Info Phase 3 Discovery agent [524778]
CBF-BS2 Drug Info Discontinued in Phase 2 Rheumatoid arthritis [546290]
Inhibitor 2'-Monophosphoadenosine 5'-Diphosphoribose Drug Info [551393]
EPIANDROSTERONE Drug Info [529971]
Hydroxyacetic Acid Drug Info [551393]
Metazamide Drug Info [537753]
Prasterone Drug Info [537753]
Modulator CBF-BS2 Drug Info [546291]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Pentose phosphate pathway
Pentose phosphate pathway (oxidative branch)
KEGG Pathway Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Central carbon metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Pentose Phosphate Pathway
Warburg Effect
Reactome TP53 Regulates Metabolic Genes
WikiPathways Sulfation Biotransformation Reaction
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Cori Cycle
Metabolism of carbohydrates
Pentose Phosphate Pathway
Glutathione metabolism
References
Ref 524778ClinicalTrials.gov (NCT02151006) Does Dehydro Epiandrosterone (DHEA) Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response?. U.S. National Institutes of Health.
Ref 527619Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology. 2005 Nov;146(11):4568-76. Epub 2005 Jun 30.
Ref 546290Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279)
Ref 529971Bioorg Med Chem. 2009 Mar 15;17(6):2483-9. Epub 2009 Feb 4.Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.
Ref 537753Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5.
Ref 546291Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279)
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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