Drug Information

Drug General Information
Drug ID
D0OW4Q
Former ID
DNC001096
Drug Name
PD-116,948
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535393], [537069], [537747]
Structure
Download
2D MOL

3D MOL
Formula
C16H24N4O2
Canonical SMILES
CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3
InChI
1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
InChIKey
FFBDFADSZUINTG-UHFFFAOYSA-N
CAS Number
CAS 102146-07-6
PubChem Compound ID
1329
PubChem Substance ID
586298, 855876, 6679288, 7422377, 7978611, 8150148, 8151091, 11110874, 11113351, 11335352, 11360591, 11363165, 11365727, 11368289, 11372005, 11374834, 11376451, 11461563, 11485531, 11489624, 11490888, 11493042, 11494085, 12014525, 14776308, 14898584, 17404944, 24277697, 24439671, 26613161, 26680127, 26747024, 26751544, 47216654, 47216983, 47216984, 47515529, 47588863, 47589184, 47810974, 47885280, 48110328, 49689246, 49689262, 50027500, 50100192, 50104134, 50104135, 53777487, 53787841
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [535393], [537069], [537747]
Adenosine receptor Target Info Antagonist [535393], [537069], [537747], [538003]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 535393Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600.
Ref 537069Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice. Przegl Lek. 2008;65(11):759-63.
Ref 537747Potent adenosine receptor antagonists that are selective for the A1 receptor subtype. Mol Pharmacol. 1987 Mar;31(3):247-52.
Ref 535393Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600.
Ref 537069Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice. Przegl Lek. 2008;65(11):759-63.
Ref 537747Potent adenosine receptor antagonists that are selective for the A1 receptor subtype. Mol Pharmacol. 1987 Mar;31(3):247-52.
Ref 538003Adenosine receptor ligands: differences with acute versus chronic treatment. Trends Pharmacol Sci. 1996 Mar;17(3):108-13.

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