Target Information

Target General Infomation
Target ID
T25663
Former ID
TTDS00185
Target Name
Adenosine receptor
Target Type
Successful
Disease Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10: J40-J44, J47]
Cardiac arrhythmias [ICD9: 427; ICD10: I47-I49]
Cystic fibrosis [ICD9: 277; ICD10: E84]
Hypertension [ICD9: 401; ICD10: I10-I16]
BioChemical Class
GPCR rhodopsin
Target Validation
T25663
Drugs and Mode of Action
Drug(s) Theophylline Drug Info Approved Chronic obstructive pulmonary disease [467474], [536481]
CPX Drug Info Phase 2 Cystic fibrosis [467606], [533629]
DIADENOSINE TETRAPHOSPHATE Drug Info Phase 2 Cardiac arrhythmias [539084]
M-216765 Drug Info Terminated Hypertension [544946]
Antagonist 8-sulfophenyl theophylline Drug Info [535393]
PD-116,948 Drug Info [535393], [537069], [537747], [538003]
SPT Drug Info [537839]
Theophylline Drug Info [536157], [536501]
Modulator CPX Drug Info [533629]
DIADENOSINE TETRAPHOSPHATE Drug Info [534273], [551871]
M-216765 Drug Info [550900]
References
Ref 467474(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 413).
Ref 467606(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 427).
Ref 533629CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells. Am J Physiol. 1995 Jul;269(1 Pt 1):C226-33.
Ref 536481Non-corticosteroid therapy for the long-term control of asthma. Expert Opin Pharmacother. 2007 Sep;8(13):2077-87.
Ref 539084(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1732).
Ref 544946Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001629)
Ref 533629CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells. Am J Physiol. 1995 Jul;269(1 Pt 1):C226-33.
Ref 534273Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol. 1996 Nov;119(5):835-44.
Ref 535393Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600.
Ref 536157Role of adenosine in airway inflammation in an allergic mouse model of asthma. Int Immunopharmacol. 2006 Jan;6(1):36-45. Epub 2005 Aug 1.
Ref 536501Emerging adenosine receptor agonists. Expert Opin Emerg Drugs. 2007 Sep;12(3):479-92.
Ref 537069Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice. Przegl Lek. 2008;65(11):759-63.
Ref 537747Potent adenosine receptor antagonists that are selective for the A1 receptor subtype. Mol Pharmacol. 1987 Mar;31(3):247-52.
Ref 537839Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J Mol Cell Cardiol. 1995 Mar;27(3):883-92.
Ref 538003Adenosine receptor ligands: differences with acute versus chronic treatment. Trends Pharmacol Sci. 1996 Mar;17(3):108-13.
Ref 550900US patent application no. 2010,0009,934, Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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