Drug General Information
Drug ID	D0PL0Y
Former ID	DIB019886
Drug Name	furtrethonium
Synonyms	furmethide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540000]
Structure		Download 2D MOL
Formula	C8H14NO+
InChI	InChI=1S/C8H14NO/c1-9(2,3)7-8-5-4-6-10-8/h4-6H,7H2,1-3H3/q+1
InChIKey	HEDXEAAVEOJUCR-UHFFFAOYSA-N
PubChem Compound ID	10938
PubChem Substance ID	6768715, 8157950, 29279296, 50260017, 57326582, 85229915, 104324683, 128047937, 135029266, 135650293, 144087362, 180370912, 198973060, 226803263, 241145013, 242549721
Target and Pathway
Target(s)	Muscarinic receptor	Target Info	Agonist	[534426]
	Muscarinic acetylcholine receptor M3	Target Info	Agonist	[534426]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway	Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
	GPCRs, Other
References
Ref 540000	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 299).
Ref 534426	Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9.

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