Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S3YN
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| Former ID |
DIB012322
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| Drug Name |
FE-202158
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| Synonyms |
V1a agonist (septic shock), Ferring; Vasopressin 1a agonist (septic shock), Ferring
|
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| Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Phase 2 | [1] | ||
| Company |
Ferring Pharmaceuticals Inc
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| Structure |
|
Download2D MOL |
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| Formula |
C46H73N13O11S2
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| Canonical SMILES |
N(CC(=O)N)C(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1NC(<br />=O)[C@@H](NC(=O)[C@H](CCCC(=O)N)NC(=O)[C@@H](NC(=O)[C@@<br />H](NC(=O)[C@@H](N)CSSC1)Cc1ccccc1)[C@@H](C)CC)CC(=O)N)C<br />CCNC(C)C
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Vasopressin V1a receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01612676) Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock. U.S. National Institutes of Health. | ||||
| REF 2 | The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-33. | ||||
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