Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S6AQ
|
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| Former ID |
DIB000800
|
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| Drug Name |
Ramorelix
|
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| Synonyms |
Hoe-013
|
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| Indication | Esophageal cancer [ICD9: 150; ICD10:C15] | Discontinued in Phase 1 | [1] | ||
| Company |
Aventis Pharma AG
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C74H95ClN16O18
|
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| Canonical SMILES |
N1(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC<br />(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C)<br />Cc2cc3c(cc2)cccc3)Cc2ccc(Cl)cc2)Cc2c[nH]c3c2cccc3)CO)Cc<br />2ccc(cc2)O)CO[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)<br />O)CC(C)C)CCCNC(=N)N)[C@H](C(=O)NNC(=O)N)CCC1
|
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| CAS Number |
CAS 127932-90-5
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gonadotropin-releasing hormone receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| GnRH signaling pathway | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Hormone ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008630) | ||||
| REF 2 | Effects of the luteinizing-hormone-releasing hormone (LHRH) antagonist ramorelix (hoe013) and the LHRH agonist buserelin on dimethylbenz[]anthracene-induced mammary carcinoma: studies with slow-release formulations. J Cancer Res Clin Oncol. 1993;119(8):457-62. | ||||
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