Drug Information

Drug General Information
Drug ID
D0U1OJ
Former ID
DIB018562
Drug Name
2MeSATP
Synonyms
2-methylthio-ATP; 2-MeSATP; 2-methylthio-adenosine-5'-triphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539064]
Structure
Download
2D MOL
Formula
C11H18N5O13P3S
InChI
InChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
InChIKey
XNOBOKJVOTYSJV-KQYNXXCUSA-N
PubChem Compound ID
5310983
PubChem Substance ID
7978586, 11056184, 14837318, 14935067, 26756665, 39340716, 53155481, 53790137, 56313303, 56314088, 103366659, 104011569, 114154974, 135651403, 162990220, 177013254, 226707142, 252333227
Target and Pathway
Target(s) P2Y11 receptor Target Info Agonist [525640]
P2Y purinoceptor 6 Target Info Agonist [534141]
P2Y purinoceptor 1 Target Info Agonist [526444]
P2Y13 receptor Target Info Agonist [526649]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptorsR-HSA-416476:G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Signal amplification
GPCR downstream signaling
References
Ref 539064(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1711).
Ref 525640Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206.
Ref 526444Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57.
Ref 526649Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.
Ref 534141Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.

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