Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T92689
|
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| Former ID |
TTDI03436
|
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| Target Name |
P2Y11 receptor
|
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| Gene Name |
P2RY11
|
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| Synonyms |
P2RY11
|
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| Target Type |
Research
|
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| UniProt ID | |||||
| Sequence |
MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRP
WHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFI TCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNC SVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTV AEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPY VGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATA APKPSEPQSRELSQ |
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| Agonist | 2MeSATP | Drug Info | [1] | ||
| ATPgammaS | Drug Info | [1] | |||
| BzATP | Drug Info | [1] | |||
| dATP | Drug Info | [1] | |||
| NAADP | Drug Info | [2] | |||
| NAD | Drug Info | [3] | |||
| NF546 | Drug Info | [4] | |||
| uridine triphosphate | Drug Info | [5] | |||
| Antagonist | NF157 | Drug Info | [6] | ||
| NF340 | Drug Info | [7] | |||
| References | |||||
| REF 1 | Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206. | ||||
| REF 2 | NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium. 2008 Apr;43(4):344-55. Epub 2007 Aug 17. | ||||
| REF 3 | Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J Biol Chem. 2006 Oct 20;281(42):31419-29. Epub 2006 Aug 22. | ||||
| REF 4 | NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47. | ||||
| REF 5 | Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling. Mol Pharmacol. 2003 Jun;63(6):1356-63. | ||||
| REF 6 | J Med Chem. 2005 Nov 3;48(22):7040-8.Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. | ||||
| REF 7 | Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal. 2006 May;2(1):1-324. | ||||
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