Drug General Information |
Drug ID |
D0U2IL
|
Former ID |
DNC004159
|
Drug Name |
2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C11H18N2O
|
Canonical SMILES |
CC(CC#CCN1CCCC1)C=NO
|
InChI |
1S/C11H18N2O/c1-11(10-12-14)6-2-3-7-13-8-4-5-9-13/h10-11,14H,4-9H2,1H3/b12-10+
|
InChIKey |
AVBRLEVRCOCAPV-ZRDIBKRKSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
Cholinergic synapse
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
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Regulation of actin cytoskeleton
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Insulin secretion
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretionhsa04020:Calcium signaling pathway
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cAMP signaling pathway
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PI3K-Akt signaling pathway
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
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PathWhiz Pathway
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Gastric Acid ProductionPW000564:Muscle/Heart Contraction
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Reactome
|
Muscarinic acetylcholine receptors
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
Acetylcholine regulates insulin secretion
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G alpha (i) signalling events
|
WikiPathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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Gastrin-CREB signalling pathway via PKC and MAPK
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Integration of energy metabolism
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Secretion of Hydrochloric Acid in Parietal Cells
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
GPCRs, Other
|
References |
REF 1 | Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). |