Drug Information

Drug General Information
Drug ID
D0UA0I
Former ID
DNAP001510
Drug Name
Metergolin
Synonyms
Liserdol (TN)
Drug Type
Small molecular drug
Indication Hyperprolactinemia; Migraine [ICD9: 253.1, 346; ICD10:E22.1, G43] Approved [551871]
Structure
Download
2D MOL

3D MOL
Formula
C25H29N3O2
Canonical SMILES
CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)CNC(=O)OCC5=CC=CC=C5
InChI
1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1
InChIKey
WZHJKEUHNJHDLS-QTGUNEKASA-N
PubChem Compound ID
28693
PubChem Substance ID
855801, 8170546, 10321618, 11466392, 11467512, 11486144, 14781460, 17405287, 22391564, 24263003, 24278105, 26751517, 26751518, 34671115, 46488055, 47721691, 47944884, 47944885, 48170512, 48244474, 48244475, 48319566, 49698459, 49899474, 50104076, 50104077, 50104078, 50558890, 51091556, 53777832, 53790927, 56311628, 56422452, 57310695, 81093356, 85231339, 85788313, 88837624, 90341228, 92125453, 92304154, 93576764, 99445342, 103183978, 103914106, 104171342, 104303418, 117580377, 121361458, 121363124
Target and Pathway
Target(s) 5-hydroxytryptamine receptor Target Info Modulator [533529], [536361]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533529Endocrine profile and therapeutic employment of a new prolactin-lowering drug, metergoline. Gynecol Obstet Invest. 1980;11(1):1-16.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.

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