Target Information

Target General Infomation
Target ID
T85605
Former ID
TTDS00097
Target Name
5-hydroxytryptamine receptor
Synonyms
5-HT receptor
Target Type
Successful
Disease Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Carcinoid syndrome [ICD10: E34.0]
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63]
Headache [ICD9: 339, 784.0; ICD10: G43-G44, R51]
Hyperprolactinemia; Migraine [ICD9:253.1, 346; ICD10: E22.1, G43]
Migraine; Cluster headaches [ICD9: 339.00, 339.01, 339.02, 346; ICD10: G43, G44.0]
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Obesity [ICD9: 278; ICD10: E66]
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
Schizophrenia [ICD9: 295; ICD10: F20]
Vomiting and nausea [ICD9: 787, 787.0; ICD10: R11]
BioChemical Class
GPCR rhodopsin
Target Validation
T85605
Drugs and Mode of Action
Drug(s) Metergolin Drug Info Approved Hyperprolactinemia; Migraine [551871]
Nafronyl Drug Info Approved Cerebrovascular ischaemia [551871]
Paliperidone Drug Info Approved Schizophrenia [524773], [542276], [551871]
Pizotyline Drug Info Approved Headache [543306], [551871]
Ramosetron Drug Info Approved Vomiting and nausea [539454], [551871]
Tandospirone Drug Info Approved Anxiety disorder [540897], [551871]
Lu-AA34893 Drug Info Phase 2 Anxiety disorder [522236]
BF-1 Drug Info Phase 1 Migraine; Cluster headaches [543126]
Fenfluramine Drug Info Withdrawn from market Obesity [467853], [537068]
Ritanserin Drug Info Discontinued in Phase 3 Anxiety disorder [543335], [544590]
HMR-2934 Drug Info Terminated Schizophrenia [536463]
REV-598 Drug Info Terminated Carcinoid syndrome [547496]
RGH-2721 Drug Info Terminated Psychotic disorders [545636]
Modulator BF-1 Drug Info [551202]
Lu-AA34893 Drug Info [551828]
Metergolin Drug Info [533529], [536361]
Nafronyl Drug Info [551871]
Pizotyline Drug Info [551871]
Ramosetron Drug Info [536361]
RGH-2721 Drug Info [545637]
Tandospirone Drug Info [536361]
Antagonist EpiCept Drug Info [536056]
Fenfluramine Drug Info [536103]
HMR-2934 Drug Info [536463]
MCI Drug Info [535109]
Paliperidone Drug Info [551871]
Ritanserin Drug Info [536044]
SB 203106 Drug Info [535385]
Inhibitor REV-598 Drug Info [547497]
References
Ref 467853(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4613).
Ref 522236ClinicalTrials.gov (NCT00622245) Efficacy and Safety of Lu AA34893 in Patients With Bipolar Depression. U.S. National Institutes of Health.
Ref 524773ClinicalTrials.gov (NCT02146547) European Long-acting Antipsychotics in Schizophrenia Trial. U.S. National Institutes of Health.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 537068Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
Ref 539454(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2301).
Ref 540897(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 55).
Ref 542276(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7258).
Ref 543126(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8424).
Ref 543306(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 93).
Ref 543335(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 97).
Ref 544590Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000237)
Ref 545636Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004008)
Ref 547496Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533529Endocrine profile and therapeutic employment of a new prolactin-lowering drug, metergoline. Gynecol Obstet Invest. 1980;11(1):1-16.
Ref 535109Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats. Chest. 2001 Feb;119(2):554-61.
Ref 5353855-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58.
Ref 536044Combined treatment of portal hypertension with ritanserin and propranolol in conscious and unrestrained cirrhotic rats. Hepatology. 1992 May;15(5):878-82.
Ref 536056Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108.
Ref 536103Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 545637Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004008)
Ref 547497Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)
Ref 551202Serotonin (5-HT2B) receptor. SciBX 4(19); doi:10.1038/scibx.2011.534. May 12 2011
Ref 551828Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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