Drug Information
Drug General Information | |||||
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Drug ID |
D0X0UR
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Former ID |
DIB020235
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Drug Name |
LPA
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Synonyms |
lysophosphatidic acid; 1-oleoyl-LPA
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539924] | ||
Structure |
Download2D MOL |
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Formula |
C21H41O7P
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InChI |
InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
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InChIKey |
WRGQSWVCFNIUNZ-KTKRTIGZSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [534686] | |
LPA5 receptor | Target Info | Agonist | [532227] | ||
Lysophosphatidate-3 receptor | Target Info | Agonist | [525588] | ||
LPA2 receptor | Target Info | Agonist | [527101] | ||
LPA6 receptor | Target Info | Agonist | [529338] | ||
P2RY10 | Target Info | Agonist | [529462] | ||
G protein coupled receptor 87 | Target Info | Agonist | [529462] | ||
Lysophosphatidic acid receptor Edg-2 | Target Info | Agonist | [530944] | ||
LPA4 receptor | Target Info | Agonist | [526616] | ||
WikiPathways | Signal Transduction of S1P Receptor | ||||
Small Ligand GPCRs | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, OtherWP2664:Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-likeWP289:Myometrial Relaxation and Contraction Pathways | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
References | |||||
Ref 525588 | Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem. 1999 Sep 24;274(39):27776-85. | ||||
Ref 526616 | Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003 Jul 11;278(28):25600-6. Epub 2003 Apr 30. | ||||
Ref 527101 | Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3473-6. | ||||
Ref 529338 | G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34. | ||||
Ref 529462 | Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12. | ||||
Ref 530944 | Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010 May 26;30(21):7300-9. | ||||
Ref 532227 | Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. | ||||
Ref 534686 | Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem. 1998 Aug 21;273(34):22105-12. |
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