Drug General Information
Drug ID
D0X5JS
Former ID
DAP001351
Drug Name
Barbituric acid
Synonyms
Barbiturate; Barbitursaeure; Malonylharnstoff; Malonylurea; Pyrimidinetriol; Pyrimidinetrione; Sodium barbiturate; Barbituric acid (VAN); AG-670/31547005; Barbituric acid (VAN) (8CI); Hexahydropyrimidine-2,4,6-trione; Hexahydro-pyrimidine-2,4,6-trione; Pyrimidine-2,4,6(1H,3H,5H)-trione; 1,2,3,4,5,6-Hexahydro-2,4,6-pyrimidinetrione; 1,3-diazinane-2,4,6-trione; 11709_FLUKA; 2,4,6(1H,3H,5H)-Pyrimidinetrione; 2,4,6-(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Pyrimidinetriol; 2,4,6-Pyrimidinetrione; 2,4,6-Trihydroxypyrimidine; 2,4,6-Trioxohexahydropyrimidine; 6-Hydroxyuracil
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536555]
Therapeutic Class
Antidepressants
Structure
Download
2D MOL

3D MOL

Formula
C4H4N2O3
Canonical SMILES
C1C(=O)NC(=O)NC1=O
InChI
1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)
InChIKey
HNYOPLTXPVRDBG-UHFFFAOYSA-N
CAS Number
CAS 67-52-7
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:16294
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555], [537688]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 537688Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.