Drug General Information
Drug ID	D0X8MZ
Former ID	DIB005689
Drug Name	Alvameline
Synonyms	Alvameline maleate; LU-25077; LU-25109; LU-31126; LU-32181; Lu-25109M
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[534674]
Company	H Lundbeck A/S
Structure		Download 2D MOL 3D MOL
Formula	C9H15N5
Canonical SMILES	c1(nn(nn1)CC)C1=CCCN(C1)C
PubChem Compound ID	178030
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M3	Target Info	Modulator	[534674]
	Muscarinic acetylcholine receptor M1	Target Info	Modulator	[534674]
	Muscarinic acetylcholine receptor M2	Target Info	Modulator	[534674]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretionhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCRs, Other
References
Ref 534674	In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40.
Ref 534674	In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40.

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