Drug General Information
Drug ID	D0Y3EG
Former ID	DIB018601
Drug Name	3-MATIDA
Synonyms	alpha-amino-5-carboxy-3-methyl-2-thiopheneacetic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540342]
Structure		Download 2D MOL
Formula	C8H9NO4S
InChI	InChI=1S/C8H9NO4S/c1-3-2-4(7(10)11)14-6(3)5(9)8(12)13/h2,5H,9H2,1H3,(H,10,11)(H,12,13)
InChIKey	KOMWRBFEDDEWEP-UHFFFAOYSA-N
PubChem Compound ID	10398360
PubChem Substance ID	15414685, 22747412, 26753227, 34117953, 77837595, 85227136, 91746224, 137270715, 162023098, 163125590, 177748547, 178100409, 204399711, 226955990, 241375815, 242136395, 245613959, 252156349
Target and Pathway
Target(s)	Metabotropicglutamate receptor 1	Target Info	Antagonist	[526337]
KEGG Pathway	Calcium signaling pathway
	FoxO signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Long-term depression
	Estrogen signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 540342	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3396).
Ref 526337	The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology. 2002 May;42(6):741-51.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.