Target Information
Target General Infomation | |||||
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Target ID |
T82083
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Former ID |
TTDI03439
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Target Name |
P2Y4 receptor
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Gene Name |
P2RY4
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Synonyms |
P2RY4
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Target Type |
Research
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UniProt ID | |||||
Sequence |
MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLF
IFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLY CSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKG TTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSR LRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSC LDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTP RADRL |
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Agonist | (N)methanocarba-UTP | Drug Info | [526232] | ||
2-amino-uridine-5'-monophosphate | Drug Info | [531402] | |||
CTP | Drug Info | [525757] | |||
ITP | Drug Info | [525757] | |||
MRS2927 | Drug Info | [531453] | |||
MRS4062 | Drug Info | [531453] | |||
N4-phenylethoxycytidine-5'-triphosphate | Drug Info | [531453] | |||
uridine triphosphate | Drug Info | [525757] | |||
UTPgammaS | Drug Info | [534221] | |||
Antagonist | PPADS | Drug Info | [529579] | ||
References | |||||
Ref 525757 | ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol. 2000 May;57(5):926-31. | ||||
Ref 526232 | Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. J Med Chem. 2002 Jan 3;45(1):208-18. | ||||
Ref 529579 | Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. | ||||
Ref 531402 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. |
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