Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T76508
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| Former ID |
TTDR00337
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| Target Name |
Mitogen-activated protein kinase kinase kinase 2
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| Gene Name |
MAP3K2
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| Synonyms |
MAPK/ERK kinase 2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; MAP3K2
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| Target Type |
Research
|
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| Function |
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
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| BioChemical Class |
Kinase
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| UniProt ID | |||||
| EC Number |
EC 2.7.11.25
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| Sequence |
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE AKLRPSADELLRHMFVHYH |
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| Pathways | |||||
| KEGG Pathway | MAPK signaling pathway | ||||
| Gap junction | |||||
| GnRH signaling pathway | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| TCR Signaling Pathway | |||||
| PANTHER Pathway | B cell activation | ||||
| EGF receptor signaling pathway | |||||
| FGF signaling pathway | |||||
| Pathway Interaction Database | ErbB1 downstream signaling | ||||
| Trk receptor signaling mediated by the MAPK pathway | |||||
| WikiPathways | Insulin Signaling | ||||
| EGF/EGFR Signaling Pathway | |||||
| MAPK Cascade | |||||
| MAPK Signaling Pathway | |||||
| BDNF signaling pathway | |||||
| IL-1 signaling pathway | |||||
| References | |||||
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