Drug Information

Drug General Information
Drug ID
D03JYN
Former ID
DNC008483
Drug Name
1-(phenyl(p-tolyl)methylene)thiosemicarbazide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529432]
Structure
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2D MOL

3D MOL
Formula
C15H15N3S
Canonical SMILES
CC1=CC=C(C=C1)C(=NNC(=S)N)C2=CC=CC=C2
InChI
1S/C15H15N3S/c1-11-7-9-13(10-8-11)14(17-18-15(16)19)12-5-3-2-4-6-12/h2-10H,1H3,(H3,16,18,19)/b17-14+
InChIKey
DZOZYORQEZEOCT-SAPNQHFASA-N
PubChem Compound ID
15722900
Target and Pathway
Target(s) Cathepsin B Target Info Inhibitor [529432]
Cathepsin L Target Info Inhibitor [529432]
KEGG Pathway Lysosome
Antigen processing and presentationhsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TCR Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Collagen degradation
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 529432Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. Epub 2008 Apr 8.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Ref 529432Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. Epub 2008 Apr 8.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.

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