Drug General Information |
Drug ID |
D0DV1O
|
Former ID |
DNC007553
|
Drug Name |
Indirubin-3-oxime
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C16H11N3O2
|
Canonical SMILES |
C1=CC=C2C(=C1)C(=C(N2)C3=C4C=CC=CC4=NC3=O)NO
|
InChI |
1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,19,21H
|
InChIKey |
LDEWQRSYYHTQRA-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
mRNA of Aurora B |
Target Info |
Inhibitor |
[1]
|
Aurora kinase A |
Target Info |
Inhibitor |
[1]
|
Aurora protein kinase |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Oocyte meiosishsa04114:Oocyte meiosis
|
Pathway Interaction Database
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Aurora B signaling
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Signaling by Aurora kinases
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Aurora C signaling
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FOXM1 transcription factor network
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Aurora A signalingaurora_b_pathway:Aurora B signaling
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Integrin-linked kinase signaling
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PLK1 signaling events
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Aurora A signaling
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Reactome
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APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
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Separation of Sister Chromatids
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Resolution of Sister Chromatid Cohesion
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RHO GTPases Activate Formins
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Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
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Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
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WikiPathways
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Mitotic Metaphase and Anaphase
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Mitotic Prometaphase
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Regulation of Microtubule Cytoskeleton
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
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JAK/STAT
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Gastric Cancer Network 1
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Integrated Breast Cancer Pathway
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APC/C-mediated degradation of cell cycle proteins
|
References |
REF 1 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. |