Drug General Information
Drug ID
D08ZZX
Former ID
DNC012769
Drug Name
4-(3-Methoxy-phenyl)-isoxazolidine-3,5-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533567]
Structure
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2D MOL

3D MOL

Formula
C10H9NO4
Canonical SMILES
COC1=CC=CC(=C1)C2C(=O)NOC2=O
InChI
1S/C10H9NO4/c1-14-7-4-2-3-6(5-7)8-9(12)11-15-10(8)13/h2-5,8H,1H3,(H,11,12)
InChIKey
GTLJNZXLCZDZRN-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [533567]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 533567J Med Chem. 1982 Jun;25(6):745-7.Isoxazolidine-3,5-diones as lens aldose reductase inhibitors.
Ref 533567J Med Chem. 1982 Jun;25(6):745-7.Isoxazolidine-3,5-diones as lens aldose reductase inhibitors.

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