| Drug General Information |
| Drug ID |
D0Q5IP
|
| Former ID |
DNC004151
|
| Drug Name |
3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H22N2
|
| Canonical SMILES |
C1CN(CCC1C2=CC=CC=C2)CC3=CNC4=CC=CC=C43
|
| InChI |
1S/C20H22N2/c1-2-6-16(7-3-1)17-10-12-22(13-11-17)15-18-14-21-20-9-5-4-8-19(18)20/h1-9,14,17,21H,10-13,15H2
|
| InChIKey |
XNXQFTTXHFQTRX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Dopaminergic synapsehsa04015:Rap1 signaling pathway
|
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cAMP signaling pathway
|
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Gap junction
|
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Dopaminergic synapse
|
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Parkinson's disease
|
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Cocaine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
|
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
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|
GPCRs, Class A Rhodopsin-like
|
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Genes and (Common) Pathways Underlying Drug Addiction
|
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
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Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
|
|
GPCRs, Other
|
| References |
| REF 1 | J Med Chem. 1996 May 10;39(10):1941-2.3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. |
|---|
