Drug Information
Drug General Information | |||||
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Drug ID |
D0I6MA
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Former ID |
DIB019704
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Drug Name |
DC-EBIO
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Synonyms |
dichloro-EBIO
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539471] | ||
Structure |
Download2D MOL |
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Formula |
C9H8Cl2N2O
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InChI |
InChI=1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)
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InChIKey |
LKHRMULASXZCLG-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
854089, 6213728, 9268126, 11111113, 11114078, 14749342, 17404997, 24278396, 47349357, 50104848, 50104849, 53777540, 56463461, 57408420, 78240964, 85231020, 85789028, 90341651, 91703976, 92303913, 93578450, 113528213, 121361254, 123088606, 124749712, 124801469, 124879972, 124879973, 128501477, 135650163, 137248073, 162022940, 162247819, 163133887, 163563824, 163564388, 163724383, 163737669, 164212502, 178125684, 219402187, 223442446, 223519285, 226913755, 241110095, 241182418
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Target and Pathway | |||||
Target(s) | KCa3.1 | Target Info | Activator | [525956] | |
KCa2.2 | Target Info | Activator | [527812] | ||
KCa2.3 | Target Info | Activator | [528912] | ||
References | |||||
Ref 525956 | Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11. | ||||
Ref 527812 | Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. J Biol Chem. 2005 Dec16;280(50):41404-11. Epub 2005 Oct 20. | ||||
Ref 528912 | Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57. |
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