Drug Information

Drug General Information
Drug ID
D01GMJ
Former ID
DNC002534
Drug Name
1,4-Dithiothreitol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C4H10O2S2
Canonical SMILES
C(C(C(CS)O)O)S
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2
InChIKey
VHJLVAABSRFDPM-UHFFFAOYSA-N
PubChem Compound ID
19001
PubChem Substance ID
603421, 3181634, 6852578, 8164181, 10519598, 14717142, 14717909, 16935602, 22389421, 29286623, 49747403, 49747404, 49747405, 49895758, 49895759, 49965679, 53788743, 56313414, 57330250, 76462155, 85085700, 85085701, 85085705, 87350420, 87560306, 87567636, 91010121, 103228142, 104346692, 109457234, 117613454, 125336023, 125536823, 125537278, 125665942, 126672542, 126674461, 127263983, 127263984, 127263985, 127263986, 127263987, 127263988, 127263989, 127263990, 127263991, 127263992, 127263993, 127263994, 127263995
Target and Pathway
Target(s) Thymidylate synthase Target Info Inhibitor [551393]
Peptidyl-prolyl cis-trans isomerase B Target Info Inhibitor [551393]
3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [551393]
BioCyc Pathway Pyrimidine deoxyribonucleotides biosynthesis from CTP
Pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleoside salvage
DTMP de novo biosynthesis (mitochondrial)
Pyrimidine deoxyribonucleosides salvagePWY-5910:Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Pyrimidine metabolism
One carbon pool by folate
Metabolic pathwayshsa00900:Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway De novo pyrimidine deoxyribonucleotide biosynthesis
Formyltetrahydroformate biosynthesisP00014:Cholesterol biosynthesis
Pathway Interaction Database E2F transcription factor networksyndecan_1_pathway:Syndecan-1-mediated signaling events
PathWhiz Pathway Pyrimidine MetabolismPW000164:Retinol MetabolismPW000050:Steroid Biosynthesis
Reactome E2F mediated regulation of DNA replication
Pyrimidine biosynthesis
G1/S-Specific TranscriptionR-HSA-1650814:Collagen biosynthesis and modifying enzymes
WikiPathways Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Integrated Pancreatic Cancer Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Metabolism of nucleotides
Fluoropyrimidine ActivityWP2725:Collagen biosynthesis and modifying enzymes
miR-targeted genes in epithelium - TarBaseWP430:Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.