| Drug General Information |
| Drug ID |
D06AGN
|
| Former ID |
DNC007555
|
| Drug Name |
Indirubin-3-acetoxime
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H13N3O3
|
| Canonical SMILES |
CC(=O)ONC1=C(NC2=CC=CC=C21)C3=C4C=CC=CC4=NC3=O
|
| InChI |
1S/C18H13N3O3/c1-10(22)24-21-16-12-7-3-5-9-14(12)19-17(16)15-11-6-2-4-8-13(11)20-18(15)23/h2-9,19,21H,1H3
|
| InChIKey |
ZGPVZKSPTYLUGW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of Aurora B |
Target Info |
Inhibitor |
[1]
|
|---|
| Aurora protein kinase |
Target Info |
Inhibitor |
[1]
|
| Aurora kinase A |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Oocyte meiosishsa04114:Oocyte meiosis
|
|
Pathway Interaction Database
|
Aurora B signaling
|
|
Signaling by Aurora kinases
|
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Aurora C signaling
|
|
FOXM1 transcription factor network
|
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Aurora A signalingaurora_b_pathway:Aurora B signaling
|
|
Integrin-linked kinase signaling
|
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PLK1 signaling events
|
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Aurora A signaling
|
|
Reactome
|
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Separation of Sister Chromatids
|
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Resolution of Sister Chromatid Cohesion
|
|
RHO GTPases Activate Formins
|
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Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
RHO GTPases Activate ForminsR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Regulation of PLK1 Activity at G2/M Transition
|
|
WikiPathways
|
Mitotic Metaphase and Anaphase
|
|
Mitotic Prometaphase
|
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Regulation of Microtubule Cytoskeleton
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
|
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JAK/STAT
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Gastric Cancer Network 1
|
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Integrated Breast Cancer Pathway
|
|
APC/C-mediated degradation of cell cycle proteins
|
| References |
| REF 1 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. |
|---|
