| Drug General Information |
| Drug ID |
D00FUS
|
| Former ID |
DNC012394
|
| Drug Name |
2-(2-Methoxy-phenyl)-1-methyl-ethylamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H15NO
|
| Canonical SMILES |
CC(CC1=CC=CC=C1OC)N
|
| InChI |
1S/C10H15NO/c1-8(11)7-9-5-3-4-6-10(9)12-2/h3-6,8H,7,11H2,1-2H3
|
| InChIKey |
VBAHFEPKESUPDE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1D receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04024:cAMP signaling pathway
|
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Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
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Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channels
|
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
|
|
Reactome
|
Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
|
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Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
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SIDS Susceptibility Pathways
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR downstream signaling
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|
GPCRs, Other
|
| References |
| REF 1 | J Med Chem. 1986 Feb;29(2):194-9.5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. |
|---|
