Drug Information

Drug General Information
Drug ID
D0X0UR
Former ID
DIB020235
Drug Name
LPA
Synonyms
lysophosphatidic acid; 1-oleoyl-LPA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539924]
Structure
Download
2D MOL
Formula
C21H41O7P
InChI
InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
InChIKey
WRGQSWVCFNIUNZ-KTKRTIGZSA-N
PubChem Compound ID
5497152
PubChem Substance ID
841493, 11695075, 14856874, 39477448, 56314106, 57364839, 77820577, 114008184, 135651509, 137104663, 139420926, 141645704, 178102052, 179661630, 223919714, 226394236, 241040659
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [534686]
LPA5 receptor Target Info Agonist [532227]
Lysophosphatidate-3 receptor Target Info Agonist [525588]
LPA2 receptor Target Info Agonist [527101]
LPA6 receptor Target Info Agonist [529338]
P2RY10 Target Info Agonist [529462]
G protein coupled receptor 87 Target Info Agonist [529462]
Lysophosphatidic acid receptor Edg-2 Target Info Agonist [530944]
LPA4 receptor Target Info Agonist [526616]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancerhsa04015:Rap1 signaling pathway
Gap junction
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathwaylysophospholipid_pathway:LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-416476:G alpha (q) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-likeWP289:Myometrial Relaxation and Contraction Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
References
Ref 539924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2906).
Ref 525588Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem. 1999 Sep 24;274(39):27776-85.
Ref 526616Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003 Jul 11;278(28):25600-6. Epub 2003 Apr 30.
Ref 527101Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3473-6.
Ref 529338G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34.
Ref 529462Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12.
Ref 530944Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010 May 26;30(21):7300-9.
Ref 532227Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.
Ref 534686Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem. 1998 Aug 21;273(34):22105-12.

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