Drug Information

Drug General Information
Drug ID
D0S5ZE
Former ID
DNC013672
Drug Name
D-192
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529420]
Structure
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2D MOL

3D MOL
Formula
C22H32N4O
Canonical SMILES
CCCN(CCN1CCN(CC1)C2=CC=CC=C2)C3CCC4=NOC=C4C3
InChI
1S/C22H32N4O/c1-2-10-25(21-8-9-22-19(17-21)18-27-23-22)14-11-24-12-15-26(16-13-24)20-6-4-3-5-7-20/h3-7,18,21H,2,8-17H2,1H3
InChIKey
FVLVETKUEQQGET-UHFFFAOYSA-N
PubChem Compound ID
24866118
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [529420]
D(3) dopamine receptor Target Info Inhibitor [529420]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 529420J Med Chem. 2008 May 22;51(10):3005-19. Epub 2008 Apr 12.Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.
Ref 529420J Med Chem. 2008 May 22;51(10):3005-19. Epub 2008 Apr 12.Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.

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