Drug General Information
Drug ID
D0S9UT
Former ID
DAP000041
Drug Name
Carmustine
Synonyms
BCNU; Becenum; Becenun; BiCNU; Bischlorethylnitrosourea; Bischlorethylnitrosurea; Bischloroethylnitrosourea; Carmubris; Carmustin; Carmustina; Carmustinum; FIVB; Gliadel; Nitrumon; BCNU [Chloroethyl nitrosoureas]; Bi CNU; Bischloroethyl nitrosourea; Bischloroethyl nitrosourea [Chloroethyl nitrosoureas]; Carmustine in ethanol; Gliadel Wafer; C 0400; DTI 015; FDA 0345; SK 27702; SRI 1720; BiCNU (TN); Bis(chloroethyl)nitrosourea; Carmustina [INN-Spanish]; Carmustinum [INN-Latin]; Bis(2-chloroethyl)nitrosourea; Carmustine (USAN/INN); Carmustine [USAN:INN:BAN]; Bis(2-chloroethyl)1-nitrosourea; Bis-N,N'-(chloroethyl)nitrosourea; Gliadel, BCNU, NSC-409962, Becenun, Carmustine; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; 1,3-BIS(CHLOROETHYL)-1-NITROSOUREA; 1,3-Bis(2-chloroethyl)-1-nitrosourea; 1,3-Bis(2-chloroethyl)nitrosourea; 1,3-Bis(beta-chloroethyl)-1-nitrosourea; 1,3-Bis(beta.-chloroethyl)-1-nitrosourea
Drug Type
Small molecular drug
Indication Brain cancer [ICD9: 191, 225.0; ICD10:C71, D33] Approved [538486], [541883]
Therapeutic Class
Anticancer Agents
Company
Bristol-Myers Squibb.
Structure
Download
2D MOL

3D MOL

Formula
C5H9Cl2N3O2
InChI
InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChIKey
DLGOEMSEDOSKAD-UHFFFAOYSA-N
CAS Number
CAS 154-93-8
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:3423
SuperDrug ATC ID
L01AD01
SuperDrug CAS ID
cas=000154938
Target and Pathway
Target(s) Human DNA Target Info Modulator [528163]
References
Ref 538486FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017422.
Ref 541883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6800).
Ref 528163Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.

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