Drug Information

Drug General Information
Drug ID
D02YCY
Former ID
DNC009270
Drug Name
(R)-11-Amino-2-methoxyaporphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [1]
Structure
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2D MOL

3D MOL
Formula
C18H20N2O
Canonical SMILES
CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)N
InChI
1S/C18H20N2O/c1-20-7-6-12-8-13(21-2)10-14-17-11(4-3-5-15(17)19)9-16(20)18(12)14/h3-5,8,10,16H,6-7,9,19H2,1-2H3/t16-/m1/s1
InChIKey
RHZAGARGKYFZJB-MRXNPFEDSA-N
PubChem Compound ID
44568533
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [1]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [1]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signaling
References
REF 1Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. Epub 2008 Jun 5.Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines.

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