Drug General Information |
Drug ID |
D0B9JP
|
Former ID |
DNC011799
|
Drug Name |
1-(3-Trifluoromethyl-phenyl)-piperazine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
|
Formula |
C11H13F3N2
|
Canonical SMILES |
C1CN(CCN1)C2=CC=CC(=C2)C(F)(F)F
|
InChI |
1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
|
InChIKey |
KKIMDKMETPPURN-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
5-hydroxytryptamine 1D receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Calcium signaling pathway
|
Neuroactive ligand-receptor interaction
|
Gap junction
|
Serotonergic synapse
|
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
Serotonergic synapsehsa04024:cAMP signaling pathway
|
PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
5HT1 type receptor mediated signaling pathway
|
Reactome
|
Serotonin receptors
|
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
G alpha (i) signalling events
|
WikiPathways
|
Serotonin Receptor 2 and STAT3 Signaling
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
SIDS Susceptibility Pathways
|
Monoamine GPCRs
|
GPCRs, Class A Rhodopsin-like
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
GPCR ligand binding
|
GPCR downstream signaling
|
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
|
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
References |
REF 1 | J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. |