Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q9YT
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| Former ID |
DAP000538
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| Drug Name |
Tetrahydrobiopterin
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| Synonyms |
Dapropterin; Kuvan; Phenoptin; Sapropterin; Sapropterina; Sapropterinum; THB; Phenylalanine hydroxylase cofactor; Sapropterin [INN]; BH4; BPH4; Kuvan (TN); R-THBP; Sapropterin (INN); Sapropterin (TN); Sapropterina [INN-Spanish]; Sapropterinum [INN-Latin]; Tetra-H-biopterin; Tetra-hydro-biopterin; Tetrahydro-6-biopterin; L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon; (-)-(6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone; (1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol; (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1H-pteridin-4-one; (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one; (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one; (6R)-L-erythro-tetrahydrobiopterin; (6R,1'R,2'S)-5,6,7,8 TETRAHYDROBIOPTERIN; 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone; 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-1H-pteridin-4-one; 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one; 5,6,7,8 Tetrahydrobiopterin; 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 5,6,7,8-erythro-tetrahydrobiopterin; 5,6,7,8-tetra-H-biopterin; 5,6,7,8-tetrahydro-L-erythrobiopterin; 5,6,7,8-tetrahydrobiopterin; 5,6,7,8-tetrahydrodictyopterin; 6R-5,6,7,8-Tetrahydrobiopterin; 6R-BH4; 6R-L-5,6,7,8-Tetrahydrobiopterin; 6R-L-erythro-5,6,7,8-tetrahydrobiopterin; 7-tetrahydrobiopterin
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Dietary supplement
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| Structure |
|
Download2D MOL |
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| Formula |
C9H15N5O3
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| InChI |
InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
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| InChIKey |
FNKQXYHWGSIFBK-RPDRRWSUSA-N
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| CAS Number |
CAS 17528-72-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3570, 7886190, 7888050, 7890758, 11567654, 14847463, 15196443, 16725801, 26738584, 34709536, 47277070, 48395336, 56312756, 57312919, 58712668, 79902433, 92298110, 93581510, 96025190, 104223501, 104234358, 104344349, 134361847, 135004616, 137210663, 137242080, 137680009, 144080912, 160852798, 162173351, 162224078, 164765359, 175267933, 178101959, 179150945, 184536615, 223573380, 223573381, 224666945, 226607067, 241112763, 242081928, 250136857, 252337579
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| ChEBI ID |
ChEBI:15372
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| SuperDrug ATC ID |
A16AX07
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| Target and Pathway | |||||
| Target(s) | Tyrosine 3-monooxygenase | Target Info | Cofactor | [536529] | |
| BioCyc Pathway | Catecholamine biosynthesis | ||||
| PathWhiz Pathway | Catecholamine Biosynthesis | ||||
| References | |||||
| Ref 537637 | Sapropterin: A New Therapeutic Agent for Phenylketonuria (September) (CE). Ann Pharmacother. 2009 Aug 4. | ||||
| Ref 540739 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5276). | ||||
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