Drug General Information
Drug ID	D0B0GC
Former ID	DIB000477
Drug Name	E-0722
Synonyms	Methosorbinil; E-79175; M-79175
Drug Type	Small molecular drug
Indication	Diabetic cataract [ICD10:E10.36, E11.36]		Terminated	[545784]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C12H11FN2O3
Canonical SMILES	[C@]12(C(=O)NC(=O)N1)c1c(O[C@@H](C2)C)ccc(c1)F
CAS Number	CAS 102916-95-0
PubChem Compound ID	175915
Target and Pathway
Target(s)	Aldose reductase	Target Info	Modulator	[533052]
BioCyc Pathway	Methylglyoxal degradation III
	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 545784	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004685)
Ref 533052	Aldose reductase inhibitors and prevention of galactose cataracts in rats. Invest Ophthalmol Vis Sci. 1989 Jul;30(7):1623-32.

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