Drug General Information
Drug ID
D0D4RT
Former ID
DNC001455
Drug Name
Tolrestat
Drug Type
Small molecular drug
Indication Diabetic cataract [ICD10:E10.36, E11.36] Withdrawn from market [534401], [542427]
Structure
Download
2D MOL

3D MOL

Formula
C16H14F3NO3S
InChI
InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
InChIKey
LUBHDINQXIHVLS-UHFFFAOYSA-N
CAS Number
CAS 4434-05-3
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:48549
SuperDrug ATC ID
A10XA01
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [537927]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 534401Effect of tolrestat, an aldose reductase inhibitor, on neutrophil respiratory burst activity in diabetic patients. Metabolism. 1997 Jun;46(6):634-8.
Ref 542427(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7404).
Ref 537927Aldose reductase inhibitors: an update. Ann Pharmacother. 1993 Jun;27(6):751-4.

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