Drug Information
Drug General Information | |||||
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Drug ID |
D0D4RT
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Former ID |
DNC001455
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Drug Name |
Tolrestat
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C16H14F3NO3S
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InChI |
InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
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InChIKey |
LUBHDINQXIHVLS-UHFFFAOYSA-N
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CAS Number |
CAS 4434-05-3
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PubChem Compound ID | |||||
PubChem Substance ID |
4773, 6595031, 7849382, 7890830, 8183065, 12014205, 14719743, 14719745, 14803262, 17422059, 26702405, 26702490, 34717457, 46508274, 46516555, 49658600, 49661446, 49972807, 57313518, 74617111, 103165598, 104301989, 109693207, 117549081, 124894577, 126522417, 126659564, 126671485, 128541561, 134339431, 134340636, 135062219, 136367754, 137003856, 142773126, 144206867, 152343606, 160965578, 162011522, 163693584, 172919741, 174530890, 178103976, 179151259, 184536599, 198944001, 210275508, 210281156, 223554755, 223682579
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ChEBI ID |
ChEBI:48549
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SuperDrug ATC ID |
A10XA01
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Target and Pathway | |||||
Target(s) | Aldose reductase | Target Info | Inhibitor | [537927] | |
NetPath Pathway | IL1 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | |||||
References | |||||
Ref 534401 | Effect of tolrestat, an aldose reductase inhibitor, on neutrophil respiratory burst activity in diabetic patients. Metabolism. 1997 Jun;46(6):634-8. | ||||
Ref 542427 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7404). |
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