Drug General Information
Drug ID
D02ONT
Former ID
DIB006959
Drug Name
5-FP
Synonyms
5-Fluoro-2(1H)-pyrimidinone
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [530233]
Structure
Download
2D MOL

3D MOL

Formula
C4H3FN2O
Canonical SMILES
C1=C(C=NC(=O)N1)F
InChI
1S/C4H3FN2O/c5-3-1-6-4(8)7-2-3/h1-2H,(H,6,7,8)
InChIKey
HPABFFGQPLJKBP-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Human DNA Target Info Binder [526595]
References
Ref 530233Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J Med Chem. 1991 Nov;34(11):3280-4.
Ref 526595Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time. Clin Cancer Res. 2003 Apr;9(4):1235-9.

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