Drug Information

Drug General Information
Drug ID
D0J0PR
Former ID
DIB001936
Drug Name
PIBROZELESIN HYDROCHLORIDE
Synonyms
KW-2189; Pibrozelesin hydrochloride < Prop INNM; 8(S)-(Bromomethyl)-2-methyl-4-(4-methylpiperazin-1-ylcarbonyloxy)-6-(5,6,7-trimethoxyindol-2-ylcarbonyl)-3,6,7,8-tetrahydrobenzo[1,2-b:4,3-b']dipyrrole-1-carboxylic acid methyl ester hydrochloride
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [545397]
Structure
Download
2D MOL

3D MOL
Formula
C32H37BrClN5O8
Canonical SMILES
COC(=O)c1c(C)[nH]c2c(OC(=O)N3CCN(C)CC3)cc4N(C[C@@H](CBr<br />)c4c12)C(=O)c5cc6cc(OC)c(OC)c(OC)c6[nH]5
InChI
1S/C32H36BrN5O8/c1-16-23(31(40)45-6)25-24-18(14-33)15-38(20(24)13-21(27(25)34-16)46-32(41)37-9-7-36(2)8-10-37)30(39)19-11-17-12-22(42-3)28(43-4)29(44-5)26(17)35-19/h11-13,18,34-35H,7-10,14-15H2,1-6H3/t18-/m1/s1
InChIKey
QRMNENFZDDYDEF-GOSISDBHSA-N
CAS Number
CAS 134106-78-8
PubChem Compound ID
6918188
Target and Pathway
Target(s) Human DNA Target Info Binder [529854]
References
Ref 545397Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003110)
Ref 529854Use of KW-2189, a DNA minor groove-binding agent, in patients with hepatocellular carcinoma: a north central cancer treatment group (NCCTG) phase II clinical trial. J Gastrointest Cancer. 2007;38(1):10-4.

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