Drug General Information
Drug ID	D0F2JY
Former ID	DIB016972
Drug Name	LY-2334737
Synonyms	Gem prodrug (cancer), Eli Lilly; Gemcitabine prodrug (cancer), Lilly
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[523989]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Formula	C17H25F2N3O5
Canonical SMILES	C1(F)(F)[C@H](n2ccc(nc2=O)NC(=O)C(CCC)CCC)O[C@@H]([C@H]<br />1O)CO
PubChem Compound ID	11646777
Target and Pathway
Target(s)	Ribonucleoside-diphosphatereductase subunit M2	Target Info	Modulator	[532325]
	Human DNA	Target Info	Modulator	[532325]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Guanosine nucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Adenosine deoxyribonucleotides de novo biosynthesis
	Guanosine deoxyribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Glutathione metabolism
	Metabolic pathways
	p53 signaling pathway
NetPath Pathway	EGFR1 Signaling Pathway
PANTHER Pathway	p53 pathway
	De novo purine biosynthesis
	De novo pyrimidine deoxyribonucleotide biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Purine Metabolism
	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Retinoblastoma (RB) in Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 523989	ClinicalTrials.gov (NCT01648764) A Study of LY2334737 in Participants With Cancer That is Advanced and/or Has Spread. U.S. National Institutes of Health.
Ref 532325	Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013 Jun;71(6):1645-55.

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