Drug Information

Drug General Information
Drug ID
D0N6FZ
Former ID
DIB015711
Drug Name
WS-50030
Synonyms
WS-50030; Dual dopamine D2 partial agonist/serotonin reuptake inhibitor (schizophrenia); Dual dopamine D2 partial agonist/serotonin reuptake inhibitor (schizophrenia), Pfizer/Solvay
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Investigative [543559]
Company
Wyeth
Structure
Download
2D MOL

3D MOL
Formula
C23H25N3O2
Canonical SMILES
C1=C(CCCN2CCN(c3cccc4c3oc(=O)[nH]4)CC2)c2c(C1)cccc2
PubChem Compound ID
44540845
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [543559]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 543559(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215).
Ref 543559(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215).

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