Drug Information
Drug General Information | |||||
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Drug ID |
D0F2NF
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Former ID |
DIB004302
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Drug Name |
GSK-958108
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Indication | Premature ejaculation [ICD9: 302.75; ICD10:F52.4] | Phase 1 | [1] | ||
Company |
GlaxoSmithKline plc
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Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 1A receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Serotonergic synapse | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
5HT1 type receptor mediated signaling pathway | |||||
Reactome | Serotonin receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT00664365) FTIH Study With GSK958108. U.S. National Institutes of Health. | ||||
REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline. | ||||
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