Target Information

Target General Infomation
Target ID
T14582
Former ID
TTDR00158
Target Name
Alanine racemase,biosynthetic
Gene Name
alr
Synonyms
AlaR; Alanine racemase; Alr; D-alanine racemase; alr
Target Type
Research
Function
Catalyzes the interconversion of L-alanine and D- alanine. Overexpression due to a natural mutation in the promoter is responsible for mediating resistance to D-cycloserine (DCS) in mycobacteria.
BioChemical Class
Racemases and epimerases
UniProt ID
P94967
EC Number
EC 5.1.1.1
Sequence
MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVART
ALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQ
VTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHG
DDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGL
SPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYR
ALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWA
ELLDTIHYEVVTSPRGRVTRTYLPAGQQD
Inhibitor (R)-4-Amino-Isoxazolidin-3-One Drug Info [551393]
3-fluorovinylglycine Drug Info [537262]
Acetate Ion Drug Info [551393]
Lysine Nz-Carboxylic Acid Drug Info [551393]
N-(5'-Phosphopyridoxyl)-D-Alanine Drug Info [551393]
Propanoic Acid Drug Info [551393]
Propionate Drug Info [535842]
Pyridoxamine-5'-Phosphate Drug Info [551393]
Pyridoxyl-Alanine-5-Phosphate Drug Info [551393]
Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate Drug Info [551393]
References
Ref 535842Molecular dynamics studies of alanine racemase: a structural model for drug design. Biopolymers. 2003 Oct;70(2):186-200.
Ref 537262Mechanism-based inactivation of alanine racemase by 3-halovinylglycines. J Biol Chem. 1991 Nov 15;266(32):21657-65.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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