Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T40730
|
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| Former ID |
TTDR00690
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| Target Name |
Dihydroneopterinaldolase
|
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| Gene Name |
folB
|
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| Synonyms |
7,8-Dihydroneopterin aldolase; DHNA; FOLB; folB
|
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| Target Type |
Research
|
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| Function |
Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin,but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin at appreciable velocity.
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| BioChemical Class |
Carbon-carbon lyase
|
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| UniProt ID | |||||
| EC Number |
EC 4.1.2.25
|
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| Sequence |
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETV
VSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKE NN |
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| Inhibitor | 2-Amino-5-Bromo-6-Phenylpyrimidin-4-Ol | Drug Info | [551393] | ||
| 6-Hydroxymethyl-7,8-Dihydropterin | Drug Info | [551393] | |||
| 7,8-dihydrobiopterin | Drug Info | [551393] | |||
| 7,8-Dihydroneopterin | Drug Info | [551393] | |||
| 8-Amino-1,3-Dimethyl-3,7-Dihydropurine-2,6-Dione | Drug Info | [551393] | |||
| 9-Methylguanine | Drug Info | [551393] | |||
| References | |||||
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