| Drug General Information |
| Drug ID |
D0F3XT
|
| Former ID |
DNC002430
|
| Drug Name |
7,8-dihydrobiopterin
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H13N5O3
|
| Canonical SMILES |
CC(C(C1=NC2=C(NC1)NC(=NC2=O)N)O)O
|
| InChI |
1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)
|
| InChIKey |
FEMXZDUTFRTWPE-UHFFFAOYSA-N
|
| CAS Number |
CAS 6779-87-9
|
| PubChem Compound ID |
|
| PubChem Substance ID |
6577875, 6591724, 16885833, 24438629, 57320075, 79660988, 103115412, 104294295, 117589164, 125334785, 126406810, 126522970, 135611007, 137188633, 138546843, 162221352, 162894998, 184568073, 237616267
|
| Target and Pathway |
| Target(s) |
Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[1]
|
|---|
| Dihydroneopterinaldolase |
Target Info |
Inhibitor |
[1]
|
| Tyrosine 3-monooxygenase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY66-301:Catecholamine biosynthesis
|
|
KEGG Pathway
|
Arginine biosynthesis
|
|
Arginine and proline metabolism
|
|
Metabolic pathways
|
|
Calcium signaling pathway
|
|
HIF-1 signaling pathway
|
|
Peroxisome
|
|
Salmonella infection
|
|
Pertussis
|
|
Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
|
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Toxoplasmosis
|
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Amoebiasis
|
|
Tuberculosis
|
|
Pathways in cancer
|
|
Small cell lung cancerhsa00350:Tyrosine metabolism
|
|
Dopaminergic synapse
|
|
Prolactin signaling pathway
|
|
Parkinson's disease
|
|
Cocaine addiction
|
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Amphetamine addiction
|
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Alcoholism
|
|
NetPath Pathway
|
IL1 Signaling Pathway
|
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IL2 Signaling Pathway
|
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PANTHER Pathway
|
Adrenaline and noradrenaline biosynthesis
|
|
Parkinson disease
|
|
Dopamine receptor mediated signaling pathway
|
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Nicotine pharmacodynamics pathway
|
|
Pathway Interaction Database
|
IL12-mediated signaling events
|
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Alpha9 beta1 integrin signaling events
|
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ATF-2 transcription factor network
|
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IL23-mediated signaling events
|
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Signaling mediated by p38-alpha and p38-beta
|
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HIF-1-alpha transcription factor networkatf2_pathway:ATF-2 transcription factor network
|
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AP-1 transcription factor network
|
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p38 signaling mediated by MAPKAP kinases
|
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Alpha-synuclein signaling
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PathWhiz Pathway
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Catecholamine Biosynthesis
|
|
Reactome
|
ROS production in response to bacteria
|
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Nitric oxide stimulates guanylate cyclase
|
|
WikiPathways
|
Type II interferon signaling (IFNG)
|
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Spinal Cord Injury
|
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AGE/RAGE pathway
|
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Effects of Nitric OxideWP727:Monoamine Transport
|
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SIDS Susceptibility Pathways
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Biogenic Amine Synthesis
|
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Dopaminergic Neurogenesis
|
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Metabolism of amino acids and derivatives
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Dopamine metabolism
|
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Parkinsons Disease Pathway
|
|
Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
