Target Information
Target General Infomation | |||||
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Target ID |
T65116
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Former ID |
TTDR01229
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Target Name |
5'-Nucleotidase
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Gene Name |
NT5E
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Synonyms |
5'-NT; CD73 antigen; Ecto-5'-nucleotidase; NT5E
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Target Type |
Research
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Function |
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
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BioChemical Class |
Phosphoric monoester hydrolases
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Target Validation |
T65116
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UniProt ID | |||||
EC Number |
EC 3.1.3.5
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Sequence |
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ |
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Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | Purine nucleotides degradation | ||||
Urate biosynthesis/inosine 5' | |||||
-phosphate degradation | |||||
Adenosine nucleotides degradation | |||||
KEGG Pathway | Purine metabolism | ||||
Pyrimidine metabolism | |||||
Nicotinate and nicotinamide metabolism | |||||
Metabolic pathways | |||||
PANTHER Pathway | Purine metabolism | ||||
Pyrimidine Metabolism | |||||
Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
Reactome | Purine catabolism | ||||
WikiPathways | Differentiation Pathway | ||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in lymphocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
Metabolism of nucleotides | |||||
References |
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