Target Information

Target General Infomation
Target ID
T69506
Former ID
TTDS00351
Target Name
Orphan nuclear receptor NR1I3
Gene Name
NR1I3
Synonyms
CAR; Constitutive androstane receptor; Nuclear receptor CAR; Orphan nuclear receptor CAR; Orphan nuclear receptor MB67; NR1I3
Target Type
Successful
Disease Nausea; Vomiting; Dizziness [ICD10: R11]
Function
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human cyp2b6 gene.
BioChemical Class
Nuclear hormone receptor
UniProt ID
Q14994
Sequence
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQV
EFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYI
KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
Drugs and Mode of Action
Drug(s) Meclizine Drug Info Approved Nausea; Vomiting; Dizziness [551871]
Inhibitor (5BETA)-PREGNANE-3,20-DIONE Drug Info [551374]
16,17-Androstene-3-Ol Drug Info [551374]
Antagonist androstanol Drug Info [534722]
androstenol Drug Info [534722]
Agonist CITCO Drug Info [526558]
TCPOBOP Drug Info [535921]
Modulator Meclizine Drug Info [536227]
Pathways
Pathway Interaction Database Glucocorticoid receptor regulatory network
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Constitutive Androstane Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526558Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem. 2003 May 9;278(19):17277-83. Epub 2003 Feb 27.
Ref 534722Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature. 1998 Oct 8;395(6702):612-5.
Ref 535921The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem. 2004 May 7;279(19):19832-8. Epub 2004 Mar 5.
Ref 536227Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab Rev. 2006;38(1-2):51-73.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.